OSMR : oncostatin M receptor
Description
The OSMR (oncostatin M receptor) is a protein-coding gene located on chromosome 5.
The OSMR gene provides instructions for producing the oncostatin M receptor beta subunit (OSMRβ) protein. This protein is a component of both the oncostatin M (OSM) receptor type II and the interleukin-31 (IL-31) receptor. These receptors are embedded in the cell membranes of various cell types throughout the body. Each receptor binds to a specific protein, like a lock and key, triggering a chain of chemical signals within the cell that regulate specific cell functions. OSM receptor type II interacts with oncostatin M (OSM). OSM signaling was initially observed to inhibit the growth of cancerous cells and is implicated in diverse bodily processes including blood cell development, cell maturation, and inflammatory responses. This signaling can also prevent cell self-destruction (apoptosis). The IL-31 receptor interacts with the protein IL-31. IL-31 signaling is involved in inflammation and itching (pruritus), though its precise role remains incompletely understood.
OSMR is also known as IL-31R-beta, IL-31RB, OSMRB, OSMRbeta, PLCA1.
