OSM
Description
The OSM (oncostatin M) is a protein-coding gene located on chromosome 22.
OSM can refer to Oncostatin-M, a human gene.
OSM, also known as Oncostatin-M, is a growth regulator that plays a multifaceted role in cellular processes. It exhibits anti-proliferative effects on several tumor cell lines, while simultaneously promoting the proliferation of AIDS-KS cells. OSM is also a key regulator of cytokine production, influencing the release of IL-6, G-CSF, and GM-CSF from endothelial cells. OSM signals through two distinct receptor complexes: type I OSM receptor, composed of LIFR and IL6ST, and type II OSM receptor, consisting of OSMR and IL6ST. Furthermore, OSM is involved in the maturation of fetal hepatocytes, contributing to liver development and regeneration.
OSM is also known as -.
Associated Diseases
- endometrial cancer
- beta-thalassemia-X-linked thrombocytopenia syndrome
- hemoglobin D disease
- alpha-thalassemia-myelodysplastic syndrome
- dehydrated hereditary stomatocytosis
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- dominant beta-thalassemia
- hemoglobin E disease
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
