OSBPL2
Description
The OSBPL2 (oxysterol binding protein like 2) is a protein-coding gene located on chromosome 20.
The OSBPL2 gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most OSBP family members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, though some possess only the sterol-binding domain. OSBPL2 encodes a protein containing solely the sterol-binding domain. In vitro studies have shown that the encoded protein binds strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but does not bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
OSBPL2 is an intracellular transport protein that binds sterols and phospholipids, facilitating lipid transport between cellular compartments. It increases cholesterol levels in the plasma membrane while reducing phosphatidylinositol-4,5-bisphosphate levels in the same membrane. OSBPL2 binds to phosphoinositides, including phosphatidylinositol-4,5-bisphosphate. It exhibits strong binding affinity for phosphatidic acid and weak binding for phosphatidylinositol 3-phosphate. In vitro studies have demonstrated its binding to cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol, and 25-hydroxycholesterol.
OSBPL2 is also known as DFNA67, DNFA67, ORP-2, ORP2.
