ORC2
Description
The ORC2 (origin recognition complex subunit 2) is a protein-coding gene located on chromosome 2.
ORC2 is a protein encoded by the ORC2 (ORC2L) gene in humans. The origin recognition complex (ORC) is a six-subunit protein complex essential for the initiation of DNA replication in eukaryotic cells. ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC2 is a subunit of the ORC complex. ORC2 forms a core complex with ORC3, ORC4, and ORC5. ORC2 also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. ORC2 has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.
ORC2 is also known as ORC2L.
