OR4E2
Description
The OR4E2 (olfactory receptor family 4 subfamily E member 2) is a protein-coding gene located on chromosome 14.
OR4E2 is a protein encoded by the OR4E2 gene in humans. Olfactory receptors like OR4E2 interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. Olfactory receptor proteins belong to a large family of G-protein-coupled receptors (GPCRs) that arise from single coding-exon genes. They share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for recognizing and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for humans is independent of other organisms.
OR4E2 is an olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups like (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide. It also binds odorants cis-cyclooctene and tert-butyl mercaptan. The receptor's activity is mediated by G proteins that activate adenylyl cyclase.
OR4E2 is also known as OR14-42.
