OPN1LW : opsin 1, long wave sensitive
Description
The OPN1LW (opsin 1, long wave sensitive) is a protein-coding gene located on chromosome X.
The OPN1LW gene provides instructions for making a protein essential for normal color vision. This protein, found in the retina, is a type of opsin pigment that is sensitive to light in the yellow/orange part of the visible spectrum. It's present in long-wavelength-sensitive or L cones, which are one of three types of cone cells in the retina. These cones work with other types of cones to produce color vision. When light hits the opsin pigment, it triggers a series of chemical reactions, altering the cell's electrical charge and generating a signal transmitted to the brain. The OPN1LW gene is located next to the OPN1MW gene on the X chromosome, both regulated by a locus control region (LCR). Normally, only the two opsin pigment genes closest to the LCR, including OPN1LW and the first copy of OPN1MW, are active in the retina and contribute to color vision.
OPN1LW is also known as CBBM, CBP, COD5, RCP, ROP.
Associated Diseases
- Colorblindness, partial, protan series
- Cone rod dystrophy
- Blue cone monochromatism
- Blue cone monochromacy
- Color vision deficiency
