OCSTAMP

---

Description

The OCSTAMP (osteoclast stimulatory transmembrane protein) is a protein-coding gene located on chromosome 20.

OCSTAMP, a probable cell surface receptor, is crucial for cellular fusion and differentiation. It collaborates with DCSTAMP to regulate cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). This protein is involved in osteoclast-mediated bone resorption, promotes osteoclast differentiation, and potentially contributes to the formation of multinucleated osteoclasts.

OCSTAMP is also known as C20orf123, OC-STAMP, dJ257E24.3.

Associated Diseases

• neutropenia-monocytopenia-deafness syndrome
• isolated asymptomatic elevation of creatine phosphokinase
• diabetes mellitus, permanent neonatal 4
• diabetes mellitus, transient neonatal, 3
• hyperinsulinism due to INSR deficiency
• permanent neonatal diabetes mellitus 1
• exercise-induced hyperinsulinism
• pentosuria
• 3-hydroxy-3-methylglutaryl-CoA synthase deficiency
• glycogen storage disorder due to hepatic glycogen synthase deficiency
• hyperinsulinism due to glucokinase deficiency
• glycogen storage disease III