OBP2A
Description
The OBP2A (odorant binding protein 2A) is a protein-coding gene located on chromosome 9.
Odorant-binding protein 2a is a protein that in humans is encoded by the OBP2A gene. This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
OBP2A is also known as LCN13, OBP, OBP2C, OBPIIa, hOBPIIa.
Associated Diseases
- cryopyrin-associated periodic syndrome
- Griscelli syndrome type 3
- pachyonychia congenita
- uncombable hair syndrome
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- Brugada syndrome
- oculocutaneous albinism type 3
- familial atrial fibrillation
- microcephaly-albinism-digital anomalies syndrome
