NXT1
Description
The NXT1 (nuclear transport factor 2 like export factor 1) is a protein-coding gene located on chromosome 20.
NXT1 is a protein located in the nuclear envelope that plays a role in nuclear export. It shares similarities with nuclear transport factor 2 and functions as a nuclear export factor in RAN- and CRM1-dependent pathways. NXT1 promotes the export of U1 snRNA, tRNA, and mRNA, and it can heterodimerize with Tap protein, potentially influencing Tap protein's ability to mediate nuclear mRNA export. Alternative polyadenylation sites have been observed for this gene.
NXT1 stimulates the export of proteins containing nuclear export signals (NES). It also participates in the nuclear export of U1 small nuclear RNA (snRNA), transfer RNA (tRNA), and messenger RNA (mRNA). NXT1 forms a heterodimer with NXF1, and this complex, along with ALYREF/THOC4 and THOC5, is involved in exporting HSP70 mRNA.
NXT1 is also known as MTR2, P15.
