NUTF2
Description
The NUTF2 (nuclear transport factor 2) is a protein-coding gene located on chromosome 16.
NUTF2 (Nuclear transport factor 2) is a protein encoded by the NUTF2 gene in humans. It functions as a cytosolic factor that aids in the transport of proteins into the nucleus. NUTF2 interacts with the nuclear pore complex glycoprotein p62, playing a role in the later stages of nuclear protein import after the initial docking of the nuclear import ligand at the nuclear envelope. NUTF2 is believed to be part of a multi-component system of cytosolic factors that assemble at the pore complex during nuclear import. NUTF2 has been shown to interact with Nucleoporin 62 and RAN.
NUTF2 facilitates the import of GDP-bound RAN from the cytoplasm into the nucleus. This process is crucial for RAN's function in cargo receptor-mediated nucleocytoplasmic transport, indirectly impacting the overall regulation of this transport. NUTF2 interacts with GDP-bound RAN in the cytoplasm, bringing it to the nuclear pore complex by binding to nucleoporins. This interaction promotes the nuclear import of RAN.
NUTF2 is also known as NTF-2, NTF2, PP15.
Associated Diseases
- cancer
- early-onset non-syndromic cataract
- cataract 46 juvenile-onset
- isolated ectopia lentis
- hereditary hyperferritinemia with congenital cataracts
- familial atrial fibrillation
- cataract
- cataract 13 with adult I phenotype
- cataract 38
