NUPR1
Description
The NUPR1 (nuclear protein 1, transcriptional regulator) is a protein-coding gene located on chromosome 16.
Nuclear protein 1 is a protein that in humans is encoded by the NUPR1 gene.
NUPR1, also known as Candidate of metastasis 1 or Protein p8, is a transcription regulator that plays a crucial role in cellular stress response. It converts stress signals into a program of gene expression, enabling cells to withstand stress caused by changes in their environment. NUPR1 is involved in regulating various cellular processes including the cell cycle, apoptosis, autophagy, and DNA repair responses. It protects cells from genotoxic stress by forming a complex with TP53 and EP300, which binds to the CDKN1A promoter, inducing its transcription. Additionally, NUPR1 interacts with various proteins like PTMA, FOXO3, and MSL1 to regulate apoptosis, autophagy, and DNA repair. Moreover, NUPR1 acts as a coactivator for PAX2 transcription factor, enhancing its activity by recruiting EP300 and suppressing PAXIP1-induced inhibition. It also regulates cell cycle progression through interactions with COPS5 and MYOD1. NUPR1 is involved in diverse biological processes, including the regulation of beta cell proliferation, LHB expression, and ovarian maturation, and plays a role in CNS inflammation and demyelination.
NUPR1 is also known as COM1, P8.
