NUP210

Description

The NUP210 (nucleoporin 210) is a protein-coding gene located on chromosome 3.

NUP210 (gp210) plays a crucial role in regulating trafficking within the eukaryotic nuclear pore complex. It anchors the pore complex to the nuclear membrane, residing primarily on the luminal side of the double-layered membrane at the pore. A specific motif in gp210 directs its sorting to the nuclear membrane, with its carboxyl tail oriented towards the cytoplasmic side of the membrane. During mitosis, the nuclear envelope disassembles into vesicles, dispersing nuclear lamina proteins and nuclear pore complexes. NUP210 is phosphorylated on its C-terminal domain at Ser1880 during mitosis, leading to its dispersal as homodimers throughout the endoplasmic reticulum. As mitosis concludes, nuclear lamins reassemble around chromosomes, but NUP210 lags behind this process. While much of the nuclear pore complex reassembly can occur without NUP210, its presence is essential for final assembly and dilation of the complexes. The replacement of serine at position 1880 with a phosphorylated glutamate in NUP210 results in a failure to reassemble, highlighting the importance of NUP210 dephosphorylation in the final stages of proper assembly.

NUP210 is also known as GP210, POM210.

Associated Diseases

WES Whole Exome Sequencing