NUMBL
Description
The NUMBL (NUMB like endocytic adaptor protein) is a protein-coding gene located on chromosome 19.
NUMBL is a protein encoded by the NUMBL gene in humans. It has been shown to interact with MAP3K7IP2.
NUMBL plays a crucial role in neurogenesis, particularly in maintaining the population of neural progenitor cells (also known as radial glial cells) during embryonic development. It influences the fate of daughter cells from these progenitors, directing them towards a progenitor fate rather than neuronal differentiation. While not essential for progenitor proliferation prior to embryonic neurogenesis, NUMBL remains important for the survival of neuroblasts in the subventricular zone (SVZ) and maintaining the integrity of the ependymal wall postnatally. Additionally, NUMBL acts as a negative regulator of the NF-κB signaling pathway. This regulation is achieved by preventing MAP3K7IP2 from interacting with ubiquitin chains of TRAF6 and RIPK1, and by promoting the degradation of TRAF6 through ubiquitination in cortical neurons.
NUMBL is also known as CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23.
Associated Diseases
- cancer
- Miyoshi myopathy
- female infertility due to oocyte meiotic arrest
- premature ovarian failure 19
- invasive hydatidiform mole
- female infertility due to zona pellucida defect
- glioblastoma
