NUMA1
Description
The NUMA1 (nuclear mitotic apparatus protein 1) is a protein-coding gene located on chromosome 11.
Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.
== Interactions == Nuclear mitotic apparatus protein 1 has been shown to interact with PIM1, Band 4.1, GPSM2 and EPB41L1.
NUMA1 is a microtubule (MT)-binding protein involved in the formation and maintenance of the spindle poles, which are crucial for the alignment and segregation of chromosomes during cell division. It tethers the minus ends of MTs at the spindle poles, ensuring their stability. NUMA1 plays a role in establishing the correct orientation of the mitotic spindle during metaphase and its elongation during anaphase. This process involves the dynein-dynactin complex, which NUMA1 recruits and anchors at the spindle poles. During anaphase, NUMA1 interacts with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) at the cell membrane, facilitating the dynein-dynactin complex recruitment and contributing to spindle elongation. NUMA1 also binds to other phosphoinositides, including phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA), and phosphatidylinositol triphosphate (PIP3). NUMA1 is required for proper spindle orientation in asymmetric cell divisions and participates in mitotic MT aster assembly and anastral spindle assembly. It positively regulates TNKS protein localization to spindle poles during mitosis. As a highly abundant component of the nuclear matrix, NUMA1 potentially plays a structural role beyond mitosis. It is essential for epidermal differentiation and hair follicle morphogenesis.
NUMA1 is also known as NMP-22, NUMA.
