NUDT2
Description
The NUDT2 (nudix hydrolase 2) is a protein-coding gene located on chromosome 9.
The NUDT2 gene encodes a member of the MutT family of nucleotide pyrophosphatases, which is a subset of the larger NUDIX hydrolase family. The protein produced by this gene possesses a modified MutT sequence motif found in certain nucleotide pyrophosphatases. It asymmetrically hydrolyzes Ap4A to produce AMP and ATP, playing a role in maintaining the intracellular level of Ap4A. The function of Ap4A is yet to be fully established. NUDT2 has been suggested as a potential tumor suppressor gene. Alternative splicing has been observed at this locus, leading to three transcript variants that all encode the same protein.
NUDT2 is also known as APAH1, IDDPN.
