NUDT12

Description

The NUDT12 (nudix hydrolase 12) is a protein-coding gene located on chromosome 5.

NUDT12 (Peroxisomal NADH pyrophosphatase NUDT12) is an enzyme encoded by the NUDT12 gene in humans. Nucleotides play a vital role in various biochemical reactions and pathways within the cell, acting as substrates, cofactors, and effectors.

NUDT12 is an mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs. This removal occurs by hydrolyzing the diphosphate linkage, producing nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is located at the 5'-end of some RNAs and, unlike the standard N7 methylguanosine (m7G) cap, promotes mRNA decay. NUDT12 preferentially acts on NAD-capped transcripts in response to nutrient stress. Additionally, it acts on free nicotinamide adenine dinucleotide molecules, hydrolyzing NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. This suggests a role in regulating the concentration of peroxisomal nicotinamide nucleotide cofactors crucial for oxidative metabolism in this organelle. NUDT12 is also involved in regulating the levels of circadian clock components PER1, PER2, PER3, and CRY2 in the liver.

NUDT12 is also known as -.

Associated Diseases

WES Whole Exome Sequencing