NUDT11
Description
The NUDT11 (nudix hydrolase 11) is a protein-coding gene located on chromosome X.
NUDT11 is a human gene that encodes the enzyme Diphosphoinositol polyphosphate phosphohydrolase 3-beta. This enzyme belongs to a group of phosphohydrolases that specifically target diphosphoinositol polyphosphates.
NUDT11 catalyzes the removal of a beta-phosphate from diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), potentially playing a role in signal transduction. It can also hydrolyze dinucleoside oligophosphates, favoring Ap6A and Ap5A as substrates. The primary products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Additionally, NUDT11 can hydrolyze 5-phosphoribose 1-diphosphate.
NUDT11 is also known as APS1, ASP1, DIPP3b, DIPP3beta, hDIPP3beta.
