NTMT1
Description
The NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1) is a protein-coding gene located on chromosome 9.
NTMT1 is a distributive alpha-N-methyltransferase that adds methyl groups to the N-terminus of specific proteins. It recognizes a sequence pattern of [Ala/Gly/Pro/Ser]-Pro-Lys at the protein's beginning, after the initial methionine (Met) is removed. NTMT1 can attach one, two, or three methyl groups to the first amino acid (Ala, Gly, or Ser) in this sequence. It also adds one or two methyl groups to Pro in the sequence Pro-Pro-Lys. Some substrates may require a preliminary single methyl group addition by NTMT2 before NTMT1 can act. NTMT1 specifically trimethylates the first Glycine (Gly) in the CENPA protein after Met removal. It is responsible for methylation at the N-terminus of several proteins including KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A, and SET. During mitosis, NTMT1 is crucial for proper bipolar spindle formation and chromosome segregation, likely through its effects on RCC1.
NTMT1 is also known as AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NRMT1, NTM1A.
