NTF3
NTF3: The Essential Neurotrophin for Neuronal Survival and Function
Description
NTF3 (Neurotrophic Factor 3) is a member of the neurotrophin family, essential for the survival, development, and function of neurons in the central and peripheral nervous systems. It plays a pivotal role in various neurophysiological processes, including neuronal growth, differentiation, and synaptic plasticity.
Associated Diseases
NTF3 has been implicated in the pathogenesis of several neurological disorders, including:
- Alzheimer's disease: Deficit in NTF3 levels has been linked to the neurodegeneration observed in Alzheimer's disease.
- Parkinson's disease: NTF3 may protect dopaminergic neurons from degeneration, which is a key feature of Parkinson's disease.
- Amyotrophic lateral sclerosis (ALS): Reduced levels of NTF3 have been associated with the progressive loss of motor neurons in ALS.
- Multiple sclerosis (MS): NTF3 has anti-inflammatory properties and may play a role in suppressing the immune response in MS.
Did you Know ?
According to a study published in the journal "Nature Neuroscience," NTF3 levels in the cerebrospinal fluid of Alzheimer's disease patients were found to be significantly reduced compared to healthy controls. This finding highlights the potential diagnostic and therapeutic implications of NTF3 in Alzheimer's disease.
