NTAN1
Description
The NTAN1 (N-terminal asparagine amidase) is a protein-coding gene located on chromosome 16.
NTAN1 (also known as PNAD) is an enzyme responsible for removing the amino group from the N-terminal asparagine residue in proteins. This process, called deamidation, converts asparagine to aspartate. This specific activity is crucial for the degradation of certain proteins within cells. The proteins targeted by NTAN1 are those that start with the amino acid sequence methionine-asparagine (Met-Asn). These proteins undergo a series of modifications, including acetylation on the methionine and removal of the acetyl group by another enzyme. The conversion of the N-terminal asparagine to aspartate by NTAN1 marks the protein for degradation via a pathway known as the N-end rule. This rule dictates that proteins with specific N-terminal amino acids are targeted for breakdown. Importantly, NTAN1 only acts on N-terminal asparagines and does not modify internal or C-terminal asparagines. It also does not act on glutamine residues or acetylated N-terminal asparagines.
NTAN1 is also known as PNAA, PNAD.
