NT5C1B-RDH14
Description
The NT5C1B-RDH14 (NT5C1B-RDH14 readthrough) is a protein-coding gene located on chromosome 2.
The NT5C1B-RDH14 fusion gene is a chimeric gene created by a chromosomal rearrangement that combines the NT5C1B gene with the RDH14 gene. This fusion gene is relatively rare and its functional significance is not fully understood. However, the encoded protein is predicted to have both 5'-nucleotidase activity and retinol dehydrogenase activity, suggesting potential roles in nucleotide metabolism and retinoid signaling pathways.
The NT5C1B-RDH14 fusion gene encodes a protein with potential dual enzymatic activities. The NT5C1B portion is predicted to function as a 5'-nucleotidase, hydrolyzing nucleoside monophosphates to nucleosides. The RDH14 portion is predicted to function as a retinol dehydrogenase, converting retinol (vitamin A) to retinaldehyde. The combined activities of this fusion protein could potentially play a role in nucleotide metabolism and retinoid signaling pathways, although its precise function in human cells remains to be determined.
NT5C1B-RDH14 is also known as AIRP, NT5C1B, cN-IB, cN1B.
