NSMCE4A
Description
The NSMCE4A (NSE4 homolog A, SMC5-SMC6 complex component) is a protein-coding gene located on chromosome 10.
Non-SMC element 4 homolog A is a protein that in humans is encoded by the NSMCE4A gene.
NSMCE4A is a component of the SMC5-SMC6 complex, which plays a crucial role in repairing DNA double-strand breaks through homologous recombination. This complex facilitates sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to the break sites. Additionally, it is essential for telomere maintenance through recombination in ALT (alternative lengthening of telomeres) cell lines. NSMCE4A contributes to the sumoylation of shelterin complex components, potentially leading to shelterin complex disassembly in ALT-associated PML bodies (APBs). Furthermore, NSMCE4A is involved in positively regulating the response to DNA damage stimuli.
NSMCE4A is also known as C10orf86, NS4EA, NSE4A.
