NRG3
Description
The NRG3 (neuregulin 3) is a protein-coding gene located on chromosome 10.
Neuregulin 3 (NRG3) is a neural-enriched protein belonging to the neuregulin family, encoded by the NRG3 gene. Neuregulins, which include NRG1, NRG2, NRG3, and NRG4, are signaling proteins that belong to the epidermal growth factor (EGF) superfamily. They share an 'EGF-like domain' with six cysteine residues and three disulfide bridges. Neuregulins are crucial for regulating the growth and differentiation of various cell types, including epithelial, glial, and muscle cells. They also play a role in cell-cell interactions in the breast, heart, and skeletal muscles. NRGs, including NRG1, NRG2, and NRG3, are prominently expressed in the central and olfactory nervous systems, suggesting their role in nervous system development, maintenance, and repair. NRGs bind to the ERBB3 and ERBB4 tyrosine kinase receptors, forming homodimers or heterodimers with ERBB2, which acts as a co-receptor. This binding triggers phosphorylation of specific tyrosine residues on the receptor, activating intracellular signaling pathways.
NRG3 is also known as HRG3, pro-NRG3.
