NRCAM
Description
The NRCAM (neuronal cell adhesion molecule) is a protein-coding gene located on chromosome 7.
NRCAM is a neuronal cell adhesion molecule encoded by the NRCAM gene in humans. It belongs to the immunoglobulin superfamily and contains multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. NRCAM is an ankyrin-binding protein involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. It is also expressed in non-neural tissues and may play a role in general cell-cell communication. Allelic variants of NRCAM have been associated with autism and addiction vulnerability. Alternative splicing produces multiple transcript variants encoding different isoforms.
NRCAM is also known as NEDNMS.
