NRAS : NRAS proto-oncogene, GTPase

Description

The NRAS (NRAS proto-oncogene, GTPase) is a protein-coding gene located on chromosome 1.

The NRAS gene provides instructions for making the N-Ras protein, which plays a crucial role in cell division by relaying signals from outside the cell to its nucleus. This signaling process instructs the cell to grow and divide or to mature and specialize. N-Ras is a GTPase, switching between active (GTP-bound) and inactive (GDP-bound) states. When bound to GTP, N-Ras transmits signals, while GDP binding inactivates it. Mutations in NRAS can lead to cancer because they can disrupt this normal regulation of cell growth and division.

The NRAS protein is a GTPase, meaning it can convert GTP into GDP. This process is essential for its function as a molecular switch, regulating cell growth and division.

NRAS is also known as ALPS4, CMNS, KRAS, N-ras, NCMS, NRAS1, NS6.

Associated Diseases

• Schimmelpenning-Feuerstein-Mims syndrome
• Noonan syndrome 6
• Thyroid cancer, nonmedullary, 2
• Colorectal cancer
• RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic
• Neurocutaneous melanosis, somatic
• Noonan syndrome
• Large congenital melanocytic nevus
• Melanocytic nevus syndrome, congenital
• Epidermal nevus, somatic
• Linear nevus sebaceus syndrome
• Autoimmune lymphoproliferative syndrome
• Epidermal nevus
• Core binding factor acute myeloid leukemia
• Cytogenetically normal acute myeloid leukemia
• Giant congenital melanocytic nevus
• Lung cancer
• Cholangiocarcinoma
• Melanoma