NR6A1
Description
The NR6A1 (nuclear receptor subfamily 6 group A member 1) is a protein-coding gene located on chromosome 9.
NR6A1 (Nuclear receptor subfamily 6, group A, member 1) is a gene that encodes the protein Germ cell nuclear factor (GCNF), also known as Retinoid receptor-related testis-associated receptor (RTR). GCNF is a member of the nuclear receptor family of intracellular transcription factors. In adults, GCNH is expressed mainly in the germ cells of gonads and is involved in the regulation of embryogenesis and germ cell differentiation. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants. During meiosis, DNA intermediates are processed as an essential step in the exchange of information between parental homologous chromosomes. The RTR complex, which consists of a type IA topoisomerase, a RecQ helicase and the structural protein RMI1, is employed in processing DNA recombination intermediates.
NR6A1 is an orphan nuclear receptor that binds to a response element containing the sequence 5'-TCAAGGTCA-3'. It may play a role in regulating gene expression during germ cell development in gametogenesis.
NR6A1 is also known as CT150, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR.
