NPY5R
npy5r
Description
npy5r, also known as nucleophosmin 1, is a protein that plays a crucial role in cellular processes such as ribosome biogenesis, cell cycle regulation, and tumor suppression. It is located in the nucleolus, a specialized region within the cell nucleus responsible for producing ribosomes, the cellular machinery that synthesizes proteins.
Associated Diseases
Mutations in the npy5r gene have been linked to several types of cancer, including:
- Acute myeloid leukemia (AML)
- Myelodysplastic syndromes (MDS)
- Chronic myelomonocytic leukemia (CMML)
- Lymphoma
- Prostate cancer
- Breast cancer
These mutations often result in an overproduction of npy5r, leading to abnormal cell growth and proliferation.
Did you Know ?
One study found that approximately 30% of AML patients have mutations in the npy5r gene. This high prevalence highlights the significant role of npy5r in the development and progression of this aggressive type of leukemia.
