NPY1R
Title: Npy1r: A Comprehensive Exploration of the Neuropeptide Y Receptor 1
Description:
Neuropeptide Y receptor 1 (npy1r) is a G protein-coupled receptor that plays a pivotal role in various physiological and pathological processes. It is predominantly expressed in the central and peripheral nervous systems, where it mediates the actions of neuropeptide Y (NPY), a potent neuropeptide involved in food intake, anxiety, and stress response.
Associated Diseases:
Dysregulation of npy1r has been implicated in several diseases, including:
- Obesity: NPY acts as a potent stimulant of food intake, and genetic variations in npy1r have been linked to an increased risk of obesity.
- Anxiety Disorders: NPY has anxiolytic effects, and reduced npy1r signaling has been associated with increased anxiety levels.
- Depression: NPY exerts antidepressant effects, and disruption of npy1r signaling may contribute to depression.
- Alzheimer's Disease: NPY is neuroprotective, and decreased npy1r expression has been observed in Alzheimer's disease patients.
Did you Know ?
In a study involving obese individuals, carriers of a specific variant of npy1r had a 30% higher body mass index (BMI) compared to non-carriers.
