NPTX2

Description

The NPTX2 (neuronal pentraxin 2) is a protein-coding gene located on chromosome 7.

NPTX2 is a gene that codes for Neuronal pentraxin-2, a protein involved in the formation of excitatory synapses. It's related to C-reactive protein and plays a role in clustering AMPA-type glutamate receptors at synapses. Increased levels of NPTX2 have been observed in Parkinson's disease tissues, suggesting its potential involvement in the pathology of the disease.

NPX2 is likely involved in modifying cellular properties that contribute to long-term plasticity. It binds to agar matrix in a calcium-dependent manner.

NPTX2 is also known as NARP, NP-II, NP2.

Associated Diseases

• nonpapillary renal cell carcinoma
• Dravet syndrome
• 7q11.23 microduplication syndrome
• schizophrenia
• microangiopathy and leukoencephalopathy, pontine, autosomal dominant
• depressive disorder
• cancer