NPSR1

Description

The NPSR1 (neuropeptide S receptor 1) is a protein-coding gene located on chromosome 7.

The neuropeptide S receptor (NPSR), also known as GPR154, is a G-protein coupled receptor that binds neuropeptide S (NPS). Increased expression of this gene is associated with asthma, and mutations in this gene have also been linked to the disease. In the central nervous system, activation of NPSR by NPS promotes arousal and anxiolytic-like effects. In the airway epithelium, activation of NPSR by NPS upregulates matrix metalloproteinases, which are involved in the pathogenesis of asthma. NPSR activation also affects gastrointestinal motility and mucosal permeability.

G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases. {ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16790440}

NPSR1 is also known as ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1.

Associated Diseases

• asthma
• low grade glioma
• eosinophil peroxidase deficiency
• linear and whorled nevoid hypermelanosis
• narcolepsy-cataplexy syndrome
• neutropenia, severe congenital, 1, autosomal dominant
• ichthyosis prematurity syndrome