NPR3
Description
The NPR3 (natriuretic peptide receptor 3) is a protein-coding gene located on chromosome 5.
NPR3, also known as natriuretic peptide receptor C/guanylate cyclase C or atrial natriuretic peptide receptor C, is a receptor for atrial natriuretic peptide. It is encoded by the NPR3 gene in humans. Natriuretic peptides, including atrial natriuretic peptide, have various vascular, renal, and endocrine effects that are crucial for maintaining blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors located in the vasculature, kidney, adrenal, and brain.
NPR3 is a receptor for the natriuretic peptide hormones, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). It binds these peptides with similar affinities. NPR3 might act as a clearance receptor for ANP, BNP, and CNP, regulating their local concentrations and effects. It might also play a role in regulating diuresis, blood pressure, and skeletal development. However, NPR3 does not possess guanylate cyclase activity.
NPR3 is also known as ANP-C, ANPR-C, ANPRC, BOMOS, C5orf23, GUCY2B, NPR-C, NPRC.
