NPM3
Description
The NPM3 (nucleophosmin/nucleoplasmin 3) is a protein-coding gene located on chromosome 10.
NPM3 is a protein encoded by the NPM3 gene in humans. It is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin, and shares high homology with the murine Npm3 gene. Due to its structural similarity to nucleoplasmin and nucleophosmin, NPM3 might be a new member of this gene family, potentially sharing basic functions with molecular chaperones.
NPM3 participates in regulating various cellular processes, including ribosome biogenesis, chromatin remodeling, and protein chaperoning. It influences the histone chaperone function and RNA-binding activity of nucleolar phosphoprotein B23/NPM. Notably, NPM3 efficiently facilitates chromatin remodeling when incorporated into a pentameric complex containing itself and NPM.
NPM3 is also known as PORMIN, TMEM123.
Associated Diseases
- cancer
- juvenile cataract-microcornea-renal glucosuria syndrome
- isolated ectopia lentis
- granular corneal dystrophy type I
- hereditary hyperferritinemia with congenital cataracts
- early-onset non-syndromic cataract
- cataract 5 multiple types
- exercise-induced hyperinsulinism
