NPFFR2
NPFFR2: A Key Regulator in Neuroinflammation and Disease
Description
Neuropeptide FF receptor 2 (NPFFR2) is a G protein-coupled receptor that binds to neuropeptide FF (NPFF), a neuropeptide involved in various physiological processes. NPFFR2 is widely expressed throughout the central and peripheral nervous systems, as well as in immune cells.
Associated Diseases
Dysregulation of NPFFR2 signaling has been linked to several neuroinflammatory and neurodegenerative diseases, including:
- Multiple sclerosis (MS): NPFFR2 is upregulated in MS lesions and may contribute to inflammation and neuronal damage.
- Alzheimer's disease (AD): NPFFR2 expression is decreased in AD brains, suggesting a role in cognitive impairment.
- Parkinson's disease (PD): NPFFR2 activation has been shown to protect against dopaminergic neuron degeneration in PD models.
- Schizophrenia: Altered NPFFR2 signaling has been implicated in the pathophysiology of schizophrenia.
- Chronic pain: NPFFR2 activation can modulate pain perception and contribute to pain chronicity.
Did you Know ?
- Approximately 30% of individuals with MS have elevated NPFFR2 expression in their cerebrospinal fluid, suggesting a potential role in disease progression.
