NOMO1
Description
The NOMO1 (NODAL modulator 1) is a protein-coding gene located on chromosome 16.
NOMO1 is a protein encoded by the NOMO1 gene in humans. It was initially thought to be related to the collagenase gene family, but subsequent research has shown its involvement in the Nodal signaling pathway during vertebrate development. NOMO1 is one of three highly similar genes located on the p arm of chromosome 16, and these genes encode closely related proteins that may have the same function. Mutations in ABCC6, a nearby gene, are associated with pseudoxanthoma elasticum (PXE), but mutations in NOMO1 itself are not.
NOMO1 is a component of the multi-pass translocon (MPT) complex, which facilitates the insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over from the SEC61 complex, occluding the lateral gate of the SEC61 complex after the initial membrane insertion of a protein's transmembrane segments. This occlusion promotes the insertion of subsequent transmembrane regions.
NOMO1 is also known as Nomo, PM5.
Associated Diseases
- type 2 diabetes mellitus
- schizophrenia
- hyperinsulinemic hypoglycemia, familial, 4
- cancer
- alcohol dependence
- COVID-19
- uterine cancer
- Lynch syndrome
- ventricular septal defect
- tricho-dento-osseous syndrome
- Marinesco-Sjogren syndrome
