NOL7
Description
The NOL7 (nucleolar protein 7) is a protein-coding gene located on chromosome 6.
Nucleolar protein 7 is a protein encoded by the NOL7 gene in humans.
NOL7 is a component of the small subunit (SSU) processome, a complex involved in the initial steps of ribosome biogenesis. The SSU processome orchestrates the transcription of the primary pre-RNA transcript and the processing of pre-18S rRNA. During SSU processome assembly within the nucleolus, NOL7 collaborates with other ribosome biogenesis factors, an RNA chaperone, and ribosomal proteins. This collective effort results in RNA folding, modifications, rearrangements, cleavage, and targeted degradation of pre-ribosomal RNA by the RNA exosome. NOL7 is essential for processing the 5'-external transcribed spacer sequence (5'ETS) of the pre-RNA transcript to generate 18S rRNA. Additionally, NOL7 plays a role in maintaining early pre-rRNA levels, possibly by aiding in its transcription or stability.
NOL7 is also known as C6orf90, PQBP3, RARG-1, dJ223E5.2.
