NOG : noggin
Description
The NOG (noggin) is a protein-coding gene located on chromosome 17.
The NOG gene provides instructions for creating a protein called noggin. This protein is essential for the development of various body tissues, including nerve tissue, muscles, and bones. Noggin's role in bone development is crucial for proper joint formation. Noggin interacts with bone morphogenetic proteins (BMPs), a group of proteins that regulate bone and tissue development. To initiate these developmental processes, BMPs bind to receptors, stimulating specific cellular activities. Noggin regulates the activity of certain BMPs by attaching to them and preventing them from binding to the receptor, ultimately reducing BMP signaling.
Inhibitor of bone morphogenetic proteins (BMP) signaling, essential for growth and patterning of the neural tube and somite. Required for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6.
NOG is also known as SYM1, SYNS1, SYNS1A.
Associated Diseases
- Tarsal-carpal coalition syndrome
- Brachydactyly, type B2
- Multiple synostoses syndrome 1
- Tarsal-Carpal coalition syndrome
- Stapes ankylosis with broad thumb and toes
- Brachydactyly type B2
- Multiple synostoses syndrome
- Proximal symphalangism
- Symphalangism, proximal, 1A
