NMRAL1
Description
The NMRAL1 (NmrA like redox sensor 1) is a protein-coding gene located on chromosome 16.
NMRAL1 is a redox sensor protein that undergoes structural changes and subcellular relocation in response to alterations in intracellular NADPH/NADP(+) levels. At low NADPH concentrations, NMRAL1 exists primarily as a monomer and binds to argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. This interaction with ASS1 inhibits its activity and reduces nitric oxide production, ultimately preventing apoptosis. At normal NADPH concentrations, NMRAL1 forms a dimer, masking the binding site for ASS1. The homodimer binds a single molecule of NADPH, exhibiting a higher affinity for NADPH compared to NADP(+). Binding to NADPH is crucial for the formation of a stable dimer. These findings are supported by experimental evidence published in PubMed IDs 17496144, 18263583, and 19254724.
NMRAL1 is also known as HSCARG, SDR48A1.
Associated Diseases
- granular corneal dystrophy type I
- X-linked endothelial corneal dystrophy
- lattice corneal dystrophy type I
- granular corneal dystrophy type II
- schizophrenia
- corneal endothelial dystrophy
- Thiel-Behnke corneal dystrophy
- macular corneal dystrophy
