NMI

Description

The NMI (N-myc and STAT interactor) is a protein-coding gene located on chromosome 2.

NMI or nmi may refer to:

NMI, also known as N-myc and STAT interactor, plays a crucial role in regulating signaling pathways, particularly within the innate immune system. It interacts with STAT proteins (except STAT2) in response to IL-2 and IFN-gamma, enhancing STAT1 and STAT5-dependent transcription. In response to IFN-alpha, NMI forms a complex with IFI35, preventing its degradation and regulating immune responses. This complex can inhibit virus-induced IFN-beta production when ubiquitinated by TRIM21. Furthermore, NMI negatively regulates NF-kappa-B signaling by blocking the nuclear translocation of p65/RELA, suppressing endothelial cell proliferation and migration. It also negatively regulates virus-induced type I interferon production by inducing IRF7 degradation. Beyond its intracellular role, NMI acts extracellularly as a DAMP (damage-associated molecular pattern) to promote inflammation. Released by macrophages during cell injury or pathogen invasion, NMI activates NF-kappa-B signaling in adjacent macrophages via TLR4 binding, leading to the release of pro-inflammatory cytokines.

NMI is also known as -.

Associated Diseases

WES Whole Exome Sequencing