NME1-NME2
Description
The NME1-NME2 (NME1-NME2 readthrough) is a protein-coding gene located on chromosome 17.
NME1-NME2, also known as NM23-LV, is a human gene. The NME1-NME2 mRNA is a naturally occurring co-transcribed product of the neighboring NME1 and NME2 genes. The significance of this co-transcribed mRNA and the function of its predicted protein product have not yet been determined. Alternative splicing of this gene results in different transcript variants encoding distinct isoforms, but the full-length nature of each variant has not been defined.
The function of the protein produced by the NME1-NME2 gene is currently unknown. The protein is likely produced from a naturally occurring co-transcribed mRNA, a product of the neighboring NME1 and NME2 genes.
NME1-NME2 is also known as NM23-LV, NMELV.
Associated Diseases
- familial adenomatous polyposis 4
- severe combined immunodeficiency due to CARD11 deficiency
- Mayer-Rokitansky-Kuster-Hauser syndrome
- hyper-IgM syndrome type 3
- hepatorenocardiac degenerative fibrosis
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- immunodeficiency 89 and autoimmunity
- severe combined immunodeficiency due to CTPS1 deficiency
- 46,XX ovotesticular disorder of sex development
- duplication of urethra
- autoimmune lymphoproliferative syndrome type 2B
- colorectal cancer
