NLRP5
Description
The NLRP5 (NLR family pyrin domain containing 5) is a protein-coding gene located on chromosome 19.
NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis. NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals. In humans, the NLRP5 protein is encoded by the NLRP5 gene.
NLRP5 is a key component of the subcortical maternal complex (SCMC) and plays a crucial role in early embryonic development. It is essential for zygotes to progress beyond the initial cell divisions by regulating actin dynamics. NLRP5 is required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which ensure symmetric division of zygotes by regulating mitotic spindle formation and positioning. Additionally, NLRP5 contributes to the localization of cortical granules to the oocyte cortex, cortical actin clearance prior to oocyte exocytosis, and the regulation of post-fertilization calcium release and endoplasmic reticulum (ER) storage. It may also be involved in localizing mitochondria in oocytes and early embryos.
NLRP5 is also known as CLR19.8, MATER, NALP5, OZEMA19, PAN11, PYPAF8.
