NLRP14
NLRP14: A Protein with a Dual Role in Inflammation and Disease
Description
NLRP14, also known as NOD-like receptor protein 14, is a protein that plays a crucial role in the innate immune system. It belongs to the intracellular pattern recognition receptor (PRR) family, which detects pathogens and triggers inflammatory responses. NLRP14 is primarily expressed in immune cells, including macrophages, dendritic cells, and neutrophils, and is involved in both the initiation and regulation of inflammation.
Associated Diseases
NLRP14 has been linked to a variety of diseases, including:
- Inflammatory bowel disease (IBD): NLRP14 is involved in the regulation of intestinal inflammation. Its dysregulation can lead to excessive inflammation and the development of IBD.
- Atherosclerosis: NLRP14 contributes to the formation of atherosclerotic plaques by promoting inflammation and foam cell formation in blood vessels.
- Cancer: NLRP14 has been found to promote tumor growth and metastasis in certain types of cancer, such as lung cancer and melanoma.
Did you Know ?
According to a study published in the journal "Nature Medicine," genetic variations in the NLRP14 gene have been associated with an increased risk of developing IBD. Individuals with specific mutations in NLRP14 were found to have a 2-fold higher risk of developing Crohn's disease.
