NLRP10

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Description

The NLRP10 (NLR family pyrin domain containing 10) is a protein-coding gene located on chromosome 11.

NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response.

NLRP10 inhibits the processing of caspase-1, the release of IL-1β dependent on caspase-1, the aggregation of PYCARD, and apoptosis mediated by PYCARD, but does not inhibit apoptosis induced by FAS or BID. It exhibits anti-inflammatory activity. NLRP10 is essential for immunity against Candida albicans infection. It is involved in the innate immune response by contributing to the release of pro-inflammatory cytokines in response to invasive bacterial infection. It contributes to T-cell-mediated inflammatory responses in the skin. It plays a role in protection against periodontitis through its involvement in the induction of IL-1A via ERK activation in oral epithelial cells infected with periodontal pathogens. NLRP10 has both ATPase and GTPase activities.

NLRP10 is also known as CLR11.1, NALP10, NOD8, PAN5, PYNOD.

Associated Diseases

• common variable immunodeficiency
• isolated agammaglobulinemia
• severe combined immunodeficiency due to CARD11 deficiency
• immunodeficiency 18
• inborn error of immunity
• immunodeficiency 25
• T-B+ severe combined immunodeficiency due to JAK3 deficiency
• hyper-IgE recurrent infection syndrome 5, autosomal recessive
• autoimmune lymphoproliferative syndrome
• severe combined immunodeficiency due to CTPS1 deficiency
• immunodeficiency 72 with autoinflammation
• immunodeficiency 62
• immunodeficiency, common variable, 14
• immunodeficiency, common variable, 4
• agammaglobulinemia 7, autosomal recessive
• hyper-IgM syndrome type 3
• combined immunodeficiency due to moesin deficiency
• autoimmune lymphoproliferative syndrome type 2B
• immunodeficiency 105
• immunodeficiency due to selective anti-polysaccharide antibody deficiency
• severe combined immunodeficiency due to LAT deficiency