NLGN4X
Description
The NLGN4X (neuroligin 4 X-linked) is a protein-coding gene located on chromosome X.
Neuroligin-4, X-linked is a protein encoded by the NLGN4X gene in humans. It is primarily expressed in the cerebral cortex and belongs to the neuroligin family of neuronal cell surface proteins. These proteins act as splice site-specific ligands for beta-neurexins and play a role in the formation and remodeling of synapses in the central nervous system. Neuroligin-4X interacts with DLG4 and mutations in its gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.
Neuroligin-4X is a cell surface protein that interacts with members of the neurexin family, facilitating cell-to-cell communication.
NLGN4X is also known as ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4.
