NLGN3
Description
The NLGN3 (neuroligin 3) is a protein-coding gene located on chromosome X.
Neuroligin-3 is a protein encoded by the NLGN3 gene in humans. It belongs to the neuroligin family of neuronal cell surface proteins, which may act as splice site-specific ligands for beta-neurexins. Neuroligins are thought to be involved in the formation and remodeling of central nervous system synapses. Mutations in the NLGN3 gene may be associated with autism spectrum disorders (ASDs). Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.
Neuroligin-3 is a cell surface protein that interacts with members of the neurexin family, playing a role in cell-cell interactions. It contributes to synapse function and synaptic signal transmission, possibly by clustering other synaptic proteins. While it may promote the initial formation of synapses, it is not essential for this process. Neuroligin-3 may also be involved in interactions between glial cells in the developing peripheral nervous system.
NLGN3 is also known as HNL3.
