NLGN2

Description

The NLGN2 (neuroligin 2) is a protein-coding gene located on chromosome 17.

Neuroligin-2 is a protein in humans encoded by the NLGN2 gene. It belongs to a family of neuronal cell surface proteins that may act as ligands for beta-neurexins. These proteins are thought to be involved in the formation and remodeling of synapses in the central nervous system.

Neuroligin-2 (NLGN2) is a transmembrane protein that plays a crucial role in cell-cell interactions, particularly in the formation and function of synapses. It interacts with members of the neurexin family, mediating these interactions both in neurons and other cell types, including pancreatic beta cells. NLGN2 is involved in synaptic signal transmission, particularly through GABA receptors, by recruiting and clustering synaptic proteins. This protein clustering activity includes promoting the assembly of GABRG2, GPHN, and LHFPL4 at the postsynaptic site. NLGN2 modulates inhibitory synaptic signaling, thereby influencing the balance between excitatory and inhibitory signals and impacting information processing within the nervous system. While essential for normal signal amplitude from inhibitory synapses, NLGN2 is not necessary for regular signal frequency. Furthermore, it may contribute to the initial formation of synapses, though this role is not essential. In controlled settings, NLGN2 can trigger the de novo formation of presynaptic structures. Beyond its neuronal roles, NLGN2 mediates cell-cell interactions between beta cells in the pancreas and modulates insulin secretion.

NLGN2 is also known as -.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing