NKG7

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Description

The NKG7 (natural killer cell granule protein 7) is a protein-coding gene located on chromosome 19.

Natural killer cell granule protein 7 is a protein that in humans is encoded by the NKG7 gene.

NKG7 plays a critical role in the immune response by regulating the release of cytotoxic granules from effector lymphocytes, such as NK cells and T cells. This process, known as exocytosis, is essential for eliminating infected or cancerous cells. NKG7 enhances the release of lytic granules containing perforin and granzyme, which are cytotoxic molecules that kill target cells. NKG7's function in regulating cytotoxic granule exocytosis contributes to the control of cancer metastasis and the resolution of infectious diseases.

NKG7 is also known as GIG1, GMP-17, p15-TIA-1.

Associated Diseases

• hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
• isolated agammaglobulinemia
• hemoglobin D disease
• alpha thalassemia-intellectual disability syndrome type 1
• delta-beta-thalassemia
• eosinophil peroxidase deficiency
• hemoglobin E-beta-thalassemia syndrome
• linear and whorled nevoid hypermelanosis
• alpha-thalassemia-myelodysplastic syndrome
• hemoglobin C-beta-thalassemia syndrome
• dominant beta-thalassemia
• Heinz body anemia