NIT1
Description
The NIT1 (nitrilase 1) is a protein-coding gene located on chromosome 1.
NIT1, also known as deaminated glutathione amidase (dGSH amidase), is a critical enzyme responsible for breaking down the amide bond within N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione). This process is essential for the repair and disposal of this harmful metabolite, preventing its accumulation within cells. NIT1 plays a significant role in regulating cell growth and apoptosis. Reduced expression of NIT1 can lead to increased cell growth, enhanced resistance to DNA damage, and an increased susceptibility to tumor formation induced by NMBA. Notably, NIT1 possesses tumor suppressor properties, enhancing the sensitivity of cancer cells to apoptosis. This effect is further strengthened in combination with the tumor suppressor activity of FHIT. Furthermore, NIT1 acts as a negative regulator of primary T-cells, influencing their activity and response.
NIT1 is also known as -.
Associated Diseases
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- lung neoplasm
- colorectal cancer
- cancer
