NGDN


Description

The NGDN (neuroguidin) is a protein-coding gene located on chromosome 14.

NGDN, also known as Neuroguidin, is a key component of the small subunit (SSU) processome, the initial precursor of the small eukaryotic ribosomal subunit. This processome assembles in the nucleolus, where NGDN interacts with various ribosome biogenesis factors, an RNA chaperone, and ribosomal proteins. These factors work together to orchestrate the folding, modification, rearrangement, and cleavage of nascent pre-ribosomal RNA (pre-rRNA). Notably, NGDN's dissociation from the complex marks the transition from the pre-A1 to pre-A1* state. Moreover, NGDN has been implicated in the regulation of mRNA translation, specifically through its ability to inhibit translation in a cytoplasmic polyadenylation element (CPE)-dependent manner.

NGDN is also known as C14orf120, CANu1, LCP5, NGD, lpd-2.

Associated Diseases



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