NFYC
Description
The NFYC (nuclear transcription factor Y subunit gamma) is a protein-coding gene located on chromosome 1.
NFYC encodes a protein that forms part of a trimeric complex, a highly conserved transcription factor. This complex binds to CCAAT motifs in gene promoter regions, regulating gene expression. NFYC forms a dimer with NFYB, which is necessary for the association of NFYA. The resulting trimer binds DNA with high specificity and affinity. Both NFYB and NFYC contain histone-like motifs, suggesting their histone-like nature. Additionally, alternative splicing may play a role in regulating NFYC expression. Two microRNAs, miR-30c and miR-30e, are located within NFYC introns and are actively transcribed in human insulin-producing beta cells. These microRNAs are essential for maintaining the differentiated phenotype of human islet beta cells.
NFYC is also known as CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC.
