NFYB
Description
The NFYB (nuclear transcription factor Y subunit beta) is a protein-coding gene located on chromosome 12.
NFYB is a protein encoded by the NFYB gene in humans. It forms part of a trimeric transcription factor complex that binds specifically to CCAAT motifs in gene promoters. This complex is highly conserved and plays a role in regulating a wide range of genes. NFYB forms a dimer with NF-YC, which is necessary for NF-YA to associate with the complex. The trimeric complex binds to DNA with high specificity and affinity. NFYB and NF-YC both contain histone-like motifs. NFYB has been shown to interact with several other proteins, including CEBPZ, CNTN2, Myc, and TBP.
NFYB is part of the NF-Y transcription factor complex, which binds specifically to the CCAAT box motif in the promoter regions of genes. NF-Y can act as both an activator and a repressor, depending on the other proteins it interacts with.
NFYB is also known as CBF-A, CBF-B, HAP3, NF-YB.
Associated Diseases
- gastric cancer
- cancer
- Ehlers-Danlos syndrome, musculocontractural type
- hereditary diffuse gastric adenocarcinoma
- Huntington disease
- qualitative or quantitative defects of dysferlin
- glioblastoma
